Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma

@article{Elliott1991PhaseIS,
  title={Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma},
  author={Thomas E. Elliott and Jan C. Buckner and Terrence L. Cascino and Ralph M Levitt and J R O'fallon and Bernd Walter Scheithauer},
  journal={Journal of Neuro-Oncology},
  year={1991},
  volume={10},
  pages={27-30}
}
Sixteen patients who developed CT or MRI scan evidence of recurrent diffuse astrocytoma after radiation therapy and nitrosourea-containing chemotherapy received ifosfamide (2500 mg/m2/day for 3 consecutive days) and mesna (500 mg/m2/dose, 5 doses/day for 3 consecutive days). Toxicity consisted primarily of leukopenia in that 60 percent of patients developed… CONTINUE READING