Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma.

@article{Yoshikawa2008PhaseIS,
  title={Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma.},
  author={Masaharu Yoshikawa and Naofumi Ono and Hiraku Yodono and Takafumi Ichida and Hironobu Nakamura},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2008},
  volume={38 5},
  pages={474-83}
}
AIM Intra-arterial cisplatin appears to have high therapeutic efficacy, but this has not been studied in detail. Accordingly, we developed a fine-powder cisplatin formulation and tested it in advanced hepatocellular carcinoma (HCC) patients in an open-label, uncontrolled study in which 27 institutions participated. METHODS The patients in this study had inoperable advanced HCC without extrahepatic metastases. All received two infusions of high-concentration cisplatin (1.43 mg/mL) via the… CONTINUE READING