Phase II study of gemcitabine plus cisplatin in metastatic breast cancer.

@article{Fuentes2006PhaseIS,
  title={Phase II study of gemcitabine plus cisplatin in metastatic breast cancer.},
  author={Homero C. Fuentes and Germ{\'a}n Calderillo and Francisco Robert Alexander and Marcelino Gallardo Ram{\'i}rez and Enrique Delgado {\'A}vila and Leonel Lazo P{\'e}rez and Guillermo Aguirre and Luis F O{\~n}ate-Oca{\~n}a and Dolores Aranda Gallardo and Jorge Pombo Otero},
  journal={Anti-cancer drugs},
  year={2006},
  volume={17 5},
  pages={
          565-70
        }
}
Our objectives were to assess the efficacy and toxicity of gemcitabine plus cisplatin as first-line therapy in metastatic breast cancer (MBC). Patients with stage IV MBC and no prior chemotherapy for metastatic disease were treated with gemcitabine 1200 mg/m on days 1 and 8, and cisplatin 75 mg/m on day 1 every 21 days. Up to 6 cycles were given. A total of 46 patients with a median age of 49 years (range 24-77) and Karnofsky performance status of 80 or above were enrolled. In total, 238 cycles… CONTINUE READING
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