Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer.

@article{Choudhury2011PhaseIS,
  title={Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer.},
  author={Ananya Sinha Choudhury and Ric Swindell and John P. Logue and P Anthony Elliott and Jacqueline Livsey and Marcus Wise and P. S. Symonds and James Pinson Wylie and Vijay Alini Chandi Ramani and Vijay Sangar and Jeanette Lyons and Ian C Bottomley and Damian McCaul and Noel W. Clarke and Anne E Kiltie and R. A. Cowan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 6},
  pages={733-8}
}
PURPOSE The aim of this prospective, phase II trial was to determine the response of muscle-invasive bladder cancer (MIBC) to concurrent chemoradiotherapy of weekly gemcitabine with 4 weeks of radiotherapy (RT; GemX). PATIENTS AND METHODS Fifty patients with transitional cell carcinoma, stage T2-3, N0, M0 after transurethral resection and magnetic resonance imaging, were recruited. Gemcitabine was given intravenously at 100 mg/m(2) on days 1, 8, 15, and 22 of a 28-day RT schedule that… CONTINUE READING
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