Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial.

@article{Galanis2013PhaseIS,
  title={Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial.},
  author={Evanthia C Galanis and Stephanie Anderson and Jackie M. Lafky and Joon H. Uhm and Caterina Giannini and Shaji K Kumar and Teresa K. Kimlinger and Donald W. Northfelt and Patrick James Flynn and Kurt A. Jaeckle and Timothy J Kaufmann and Jan C. Buckner},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 17},
  pages={4816-23}
}
PURPOSE We hypothesized that vertical blockade of VEGF signaling by combining bevacizumab with sorafenib in patients with recurrent glioblastoma would result in a synergistic therapeutic effect. We also investigated whether VEGF, VEGFR2 and hypoxia-inducible factor-1α single-nucleotide polymorphisms (SNP), circulating biomarkers of angiogenesis, and MRI markers such as apparent diffusion coefficient (ADC) are correlated with treatment efficacy and/or toxicity. EXPERIMENTAL DESIGN Patients… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

A randomized phase II study of bevacizumab versus bevacizumab plus lomustine versus lomustine single agent in recurrent glioblastoma: the Dutch BELOB study

  • W Taal, HM Oosterkamp, AME Walenkamp, L Victor Beerepoot, M Hanse, J Buter
  • J Clin Oncol 2013;31:114s
  • 2013
2 Excerpts

A randomized phase II study of carboplatin and bevacizumab in recurrent glioblastoma multiforme (CABARET)

  • K Maree Field, J Simes, H Wheeler, EJ Hovey, AK Nowak, L Cher
  • J Clin Oncol
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…