Phase II randomized trial of two nonoperative regimens of induction chemotherapy followed by chemoradiation in patients with localized carcinoma of the esophagus: RTOG 0113.

@article{Ajani2008PhaseIR,
  title={Phase II randomized trial of two nonoperative regimens of induction chemotherapy followed by chemoradiation in patients with localized carcinoma of the esophagus: RTOG 0113.},
  author={Jaffer A. Ajani and Kathryn Winter and Ritsuko Komaki and David Paul Kelsen and Bruce Daniel Minsky and Zhongxing Liao and Jeffrey C Bradley and Mitchel L Fromm and David Hornback and Christopher G Willett},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 28},
  pages={4551-6}
}
PURPOSE Two nonoperative approaches (one without fluorouracil) using induction chemotherapy and then definitive chemoradiotherapy developed at two centers were compared in patients with localized esophageal cancer (LEC). The primary end point was to assess whether any approach would achieve a >or= 77.5% 1-year survival rate, surpassing the historical 66% rate from the Radiation Therapy Oncology Group (RTOG) protocol 9405. PATIENTS AND METHODS In a multi-institutional cooperative group setting… CONTINUE READING

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