Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study.

@article{Boven1992PhaseIP,
  title={Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study.},
  author={Epie Boven and Benjamin Winograd and Dietmar P. Berger and Matthew P Dumont and Boudewijn J. M. Braakhuis and Oystein Fodstad and Scott Langdon and Heinz Herbert Fiebig},
  journal={Cancer research},
  year={1992},
  volume={52 21},
  pages={5940-7}
}
In a European joint project carried out in 6 laboratories a disease-oriented program was set up consisting of a panel of 7 tumor types, each represented by 4 to 8 different human tumor lines, for secondary screening of promising anticancer drugs. Human tumor lines were selected on the basis of differences in histology, growth rate, and sensitivity to conventional cytostatic agents. Xenografts were grown s.c. in nude mice, and treatment was started when tumors reached a mean diameter of 6 mm in… CONTINUE READING
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