Phase II evaluation of chlorozotocin (NSC-178248) in advanced human cancer.

@article{Talley1981PhaseIE,
  title={Phase II evaluation of chlorozotocin (NSC-178248) in advanced human cancer.},
  author={Robert W. Talley and Michael K. Samson and Robert W. Brownlee and A M Samhouri and R J Fraile and Laurence H. Baker},
  journal={European journal of cancer},
  year={1981},
  volume={17 3},
  pages={
          337-43
        }
}
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References

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Phase I trial of chlorozotocin.
TLDR
Chlorozotocin was given to 37 patients with advanced malignant tumors in a daily X 5 schedule at 6-week intervals, with no major antitumor activity occurred; however, three patients with renal cell carcinoma and one patient each with lung cancer, ovarian carcinoma, and Hodgkin's disease had minor objective decreases in tumor size.
Phase I studies on chlorozotocin
TLDR
Based on these studies, the recommended dose for phase II investigation of chlorozotocin is 120 mg/m2 every 6 wk, and there were objective signs of therapeutic activity in 5 patients, 3 of whom had melanoma.
Pharmacology of chlorozotocin Nsc-178248), a new nitrosourea antitumor agent.
TLDR
If aminoglucose modification of nitrosourea bone marrow toxicity can be confirmed in man without significant loss of antitumor activity, the use of such a compound could facilitate treatment of patients with neoplastic disease who have pre-existing abnormal bone marrow function.
Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose, an antitumor agent with modified bone marrow toxicity.
TLDR
If the antitumor activity and reduced bone marrow toxicity of chlorozotocin are confirmed in man the use of this compound would facilitate treatment of patients with neoplastic disease who have preexisting abnormal bone marrow function or would allow for the more effective use of a nitrosourea agent in combination with anticancer agents possessing more potent myelosuppressive properties.