Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line.

@article{Miyake2014PhaseIE,
  title={Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line.},
  author={Seiji Miyake and Saori Kobayashi and Kazuo Tsubota and Yoko Ozawa},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 2},
  pages={535-40}
}
The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to… CONTINUE READING
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