Phase II dose-response trials: A simulation study to compare analysis method performance under design considerations.

Abstract

Phase II trials are intended to provide information about the dose-response relationship and to support the choice of doses for a pivotal phase III trial. Recently, new analysis methods have been proposed to address these objectives, and guidance is needed to select the most appropriate analysis method in specific situations. We set up a simulation study to… (More)
DOI: 10.1080/10543406.2017.1293078

Cite this paper

@article{Rekowski2017PhaseID, title={Phase II dose-response trials: A simulation study to compare analysis method performance under design considerations.}, author={Jan Rekowski and Claudia K{\"o}llmann and Bj{\"o}rn Bornkamp and Katja Ickstadt and Andr{\'e} Scherag}, journal={Journal of biopharmaceutical statistics}, year={2017}, pages={1-17} }