Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer.

@article{Sato2007PhaseIT,
  title={Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and irinotecan plus radiation in patients with locally advanced rectal cancer.},
  author={T Shun Sato and Yukihito Kokuba and Wasaburo Koizumi and Kazushige Hayakawa and Isao Okayasu and Masahiko Watanabe},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={69 5},
  pages={1442-7}
}
PURPOSE To determine the maximum tolerated dose (MTD) and recommended dose (RD) of irinotecan combined with preoperative chemoradiotherapy with S-1 in patients with locally advanced rectal cancer. PATIENTS AND METHODS We gave preoperative radiotherapy (total dose, 45 Gy) to 23 patients with locally advanced (T3/T4) rectal cancer. Concurrently, S-1 was given orally at a fixed dose of 80 mg/m2/day on Days 1-5, 8-12, 22-26, and 29-33, and irinotecan was given as a 90-min continuous i.v. infusion… CONTINUE READING

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