Phase I trial of multiple cycles of high-dose carboplatin, paclitaxel, and topotecan with peripheral-blood stem-cell support as front-line therapy.

@article{Schilder2001PhaseIT,
  title={Phase I trial of multiple cycles of high-dose carboplatin, paclitaxel, and topotecan with peripheral-blood stem-cell support as front-line therapy.},
  author={Russell Schilder and James M. Gallo and Michael M. Millenson and Michael A. Bookman and Louis M. Weiner and Andr{\'e} Rogatko and B. J. Rogers and K Padavic-Shallers and Matthew P Boente and Norman P Rosenblum and Andrea L. Adams and Suzanne L. Ciccotto and Robert F. Ozols},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2001},
  volume={19 4},
  pages={1183-94}
}
PURPOSE To determine the safety and feasibility of delivering multiple cycles of front-line high-dose carboplatin, paclitaxel, and topotecan with peripheral-blood stem-cell (PBSC) support. PATIENTS AND METHODS Patients were required to have a malignant solid tumor for which they had received no prior chemotherapy. Mobilization of PBSC was achieved with either filgrastim alone or in combination with cyclophosphamide and paclitaxel. Patients then received three or four cycles of high-dose… CONTINUE READING

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