Corpus ID: 221202879

Phase I trial of glycolitic inhibition with 2-deoxyglucose and docetaxel for patients with solid tumors

@article{Raez2006PhaseIT,
  title={Phase I trial of glycolitic inhibition with 2-deoxyglucose and docetaxel for patients with solid tumors},
  author={Luis E. Raez and Virginia K. Langmuir and Kyriakos Papadopoulus and Alejandro Daniel Ricart and Caio Max S Rocha-Lima and Joseph D. Rosenblatt and James J. Schlesselman and Alan B Colowick and Don Jung and Theodore J. Lampidis},
  journal={Cancer Research},
  year={2006},
  volume={66},
  pages={121-122}
}
515 Background: The slow growing cell population of solid tumors that is associated with hypoxia presents a formidable mode of resistance to chemotherapeutic agents; however anaerobic metabolism of these tumor cells also provides a window of selectivity for glycolytic inhibitors, such as 2-deoxy-D-glucose (2DG). Thus, the combination of chemotherapy (targets rapidly dividing cells) and 2DG (selectively killing the slow growing population) is expected to be more effective than either agent alone… Expand
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