Phase I trial of elactocin.

@article{Newlands1996PhaseIT,
  title={Phase I trial of elactocin.},
  author={Edward Stewart Newlands and GordonJ. S. Rustin and M. H. Brampton},
  journal={British Journal of Cancer},
  year={1996},
  volume={74},
  pages={648 - 649}
}
Elactocin is a novel anti-tumour antibiotic which has potent activity in vitro against a range of tumours. This phase I trial of elactocin identified the dose-limiting toxicity as profound anorexia and malaise. The schedules used included 1 h infusion 3 weekly, 24 h infusion 3 weekly, 1 h infusion daily x 5 (3 weekly), 1 h infusion weekly and finally continuous 5 day intravenous infusion. On all these schedules dose-limiting toxicity was the same and as no partial or complete responses were… CONTINUE READING
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