Phase I study of vinorelbine and paclitaxel by 3-hour simultaneous infusion with and without granulocyte colony-stimulating factor support in metastatic breast carcinoma.

@article{Ibrahim2001PhaseIS,
  title={Phase I study of vinorelbine and paclitaxel by 3-hour simultaneous infusion with and without granulocyte colony-stimulating factor support in metastatic breast carcinoma.},
  author={Nuhad K. Ibrahim and Aman U. Buzdar and Vicente Valero and Kapil Dhingra and Jie Willey and Gabriel N Hortobagyi},
  journal={Cancer},
  year={2001},
  volume={91 4},
  pages={664-71}
}
BACKGROUND The purpose of the study was to determine the maximum tolerated dose (MTD) of vinorelbine and paclitaxel given concomitantly in patients with advanced breast carcinoma, the toxicity of this combination, and whether the addition of granulocyte colony-stimulating factor (G-CSF) would allow administration of higher doses of the combination. METHODS Between January 1994 and January 1995, 38 patients were entered on this study. All patients received vinorelbine and paclitaxel… CONTINUE READING