Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies.

@article{Saif2010PhaseIS,
  title={Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies.},
  author={Muhammad Wasif Saif and Frederick Lansigan and Shah Ruta and Lynne Lamb and M Mezes and Kyle T Elligers and Nicole Drbohlav Grant and Z-L Jiang and Shih Hao Liu and Y-C Cheng},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2010},
  volume={17 3-4},
  pages={161-9}
}
PURPOSE The botanical formulation, PHY906, has been used widely in Eastern countries to treat gastrointestinal symptoms including diarrhea, nausea and vomiting. PHY906 may also have anti-tumor properties and may potentiate the action of several chemotherapeutic agents based on pre-clinical studies. We conducted a Phase I study using PHY906 in combination with capecitabine in patients with advanced pancreatic and gastrointestinal malignancies to determine the maximum tolerated dose (MTD) of… CONTINUE READING
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