Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules.

Abstract

PURPOSE To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen. EXPERIMENTAL DESIGN In this phase I study, we administered one or two cycles of four triweekly s.c./intradermal injections of ex vivo generated dendritic cells modified with a recombinant… (More)

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@article{Morse2005PhaseIS, title={Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules.}, author={Michael Andew Morse and Timothy M. Clay and Amy C. Hobeika and Takuya Osada and Shubi Khan and Stephen Chui and Donna Niedzwiecki and Dennis L. Panicali and Jeffrey Schlom and H. Kim Lyerly}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2005}, volume={11 8}, pages={3017-24} }