Phase I study of cefixime, a new oral cephalosporin.

  title={Phase I study of cefixime, a new oral cephalosporin.},
  author={Mitsuyoshi Nakashima and Toshihiko Uematsu and Yoshiharu Takiguchi and Mitsutaka Kanamaru},
  journal={Journal of clinical pharmacology},
  volume={27 5},
The tolerance to and pharmacokinetics of cefixime, a new oral cephalosporin, were evaluated in healthy volunteers given the drug in single doses of 50, 100 and 200 mg and repeated doses of 200 mg bid for 14 days. In the repeated-dose study, there were mild and transient subjective symptoms such as soft stools, diarrhea, and anorexia, which disappeared without additional treatment during the dosing period. Slight increases in eosinophil and serum amylase levels were also observed. The serum… CONTINUE READING

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