Phase I study of carboplatin combined with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer.

@article{Takeoka2014PhaseIS,
  title={Phase I study of carboplatin combined with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer.},
  author={Hiroaki Takeoka and Kazuhiko Yamada and Koichi Azuma and Yoshiaki Zaizen and Fumie Yamashita and Tsukasa Yoshida and Yoshiko Naito and Yusuke Okayama and Maki Miyamoto and Tomoaki Hoshino},
  journal={Japanese journal of clinical oncology},
  year={2014},
  volume={44 5},
  pages={472-8}
}
OBJECTIVE The primary objective of this study was to evaluate the safety and tolerability of carboplatin plus pemetrexed for elderly patients (≥75 years) with chemotherapy-naïve advanced non-squamous non-small cell lung cancer. METHODS Patients received escalated doses of carboplatin at an area under the concentration-time curve of 4 (Level 1) or 5 (Level… CONTINUE READING