Phase I study of amphotericin B colloidal dispersion for the treatment of invasive fungal infections after marrow transplant.

@article{Bowden1996PhaseIS,
  title={Phase I study of amphotericin B colloidal dispersion for the treatment of invasive fungal infections after marrow transplant.},
  author={Raleigh A. Bowden and M J Cays and Ted Gooley and Richard D. Mamelok and Jo-Anne van Burik},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 5},
  pages={1208-15}
}
Amphotericin B colloidal dispersion (ABCD; Amphocil) was evaluated in a phase I dose-escalation study in 75 marrow transplant patients with invasive fungal infections (primarily Aspergillus or Candida species) to determine the toxicity profile, maximum tolerated dose, and clinical response. Escalating doses of 0.5-8.0 mg/kg in 0.5-mg/kg/patient increments were given up to 6 weeks. No infusion-related toxicities were observed in 32% of the patients; 52% had grade 2 and 5% had grade 3 toxicity… CONTINUE READING

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