Phase I study of Doxil and vinorelbine in metastatic breast cancer.

@article{Burstein1999PhaseIS,
  title={Phase I study of Doxil and vinorelbine in metastatic breast cancer.},
  author={Harold J. Burstein and Michael J. Ramirez and William P. Petros and Keith D. Clarke and Marc A. Warmuth and Paul Kelly Marcom and Ursula A. Matulonis and Leroy Monroe Parker and Lydsay N. Harris and Eric P. Winer},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1999},
  volume={10 9},
  pages={1113-6}
}
BACKGROUND Vinorelbine and Doxil (liposomal doxorubicin) are active chemotherapeutic agents in metastatic breast cancer. A phase I study was designed to evaluate combination therapy. PATIENTS AND METHODS Thirty women with metastatic breast cancer were enrolled. Dose-limiting toxicity was determined through a dose escalation scheme, and defined for the first treatment cycle, only. Pharmacokinetic studies were performed during the first cycle of treatment. RESULTS In the first cohort of Doxil… CONTINUE READING

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