Phase I study of 3-weekly docetaxel, capecitabine and oxaliplatin combination chemotherapy in patients with previously untreated advanced gastric cancer

@article{Sym2009PhaseIS,
  title={Phase I study of 3-weekly docetaxel, capecitabine and oxaliplatin combination chemotherapy in patients with previously untreated advanced gastric cancer},
  author={Sun Jin Sym and Min-Hee Ryu and Hye Jin Kang and Sung Sook Lee and Heung Moon Chang and Jae Lyun Lee and Tae Won Kim and Jeong Hwan Yook and Sung Tae Oh and Byung Sik Kim and Yoon-koo Kang},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2009},
  volume={66},
  pages={373-380}
}
Adding docetaxel to cisplatin and 5-fluorouracil (5-FU) (DCF) significantly improved clinical efficacy in advanced gastric cancer (AGC). To further improve the efficacy and tolerability, we substituted oxaliplatin for cisplatin and capecitabine for 5-FU in the DCF regimen and performed a phase I study to determine the recommended dose (RD) and dose-limiting toxicity (DLT) of docetaxel, capecitabine and oxaliplatin (DXO) combination in patients with AGC. Previously untreated patients with… CONTINUE READING

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