Phase I study and pharmacological analysis of cis-diammine(glycolato)platinum (254-S; NSC 375101D) administered by 5-day continuous intravenous infusion.

@article{Sasaki1991PhaseIS,
  title={Phase I study and pharmacological analysis of cis-diammine(glycolato)platinum (254-S; NSC 375101D) administered by 5-day continuous intravenous infusion.},
  author={Yasutsuna Sasaki and Toshiyasu Amano and Masashige Morita and Tetsu Shinkai and Kenji Eguchi and Tomohide Tamura and Yuichiro Ohe and Akira Kojima and Nagahiro George Saijo},
  journal={Cancer research},
  year={1991},
  volume={51 5},
  pages={1472-7}
}
A phase I study of cis-diammine(glycolato)platinum (254-S; NSC 375101D) was conducted in 15 patients with refractory or relapsing malignancy by 5-day continuous i.v. infusion. Three to 5 patients per dose were given 50, 75, 87.5, or 100 mg/m2/120 h (10-20 mg/m2 daily for 5 days). Toxicity evaluation and pharmacokinetic analysis were performed in 15 and 14 patients, respectively. Thrombocytopenia and neutropenia were the dose-limiting toxicities at the maximum tolerated dose of 87.5 mg/m2/120 h… CONTINUE READING
28 Citations
38 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Pharmacokinetics of (glycolato-O.O')-diamniine plalinum(II). a new platinum derivative, ¡ncomparison with cisplatin and earboplatin

  • Sasaki, N Saijo.
  • C'an cer Chemothcr. Pharmacol.
  • 1989
Highly Influential
4 Excerpts

Prediction by creatinine clearance of thrombocytopenia and recommended dose in patients receiving (glycolato-O.W)diammine platinum(ll) (NSC' 375IOID)

  • V Sasaki, A. Ohe. .'.. Vamada. K.. Kojima, K.. Nakagawa, N. Saijo
  • Jpn. J. Cancer Res.
  • 1990

A phase I clinical and pharmacokinetic study of earboplatin and autologous bone marrow

  • E Schnipper.I...Frei.
  • support. J. din. Oncol.
  • 1989
2 Excerpts

A phase I clinical and pharmacokinetic study of earboplatin and autologous bone marrow support

  • C Eder.J.P..Animan.K..Begg., D. Henner.W.
  • Clin . Oncol . .
  • 1989

I..and Niitani.H. Phase II clinical studv of(glycolatoO,O')diammine plalinum(ll) (254-S). a new platinum complex, for primary lung cancer

  • Proc. Am. Soc. Clin. Oncol.
  • 1989
1 Excerpt

Two-rmu.c 24-hour infusion of cisplatin: pharmacokinetic considerations

  • R.G.. Gill. P. Ci, L Olweny.C.
  • Clin. Oncol.
  • 1989
3 Excerpts

Antitumor activity of a new platinum compound (glycolato-ftO')-diammine platinum(ll) (254-S). against non-small cell lung carcinoma grown in a human tumor clonogenic assay system

  • F. Kanawa, Sasaki, N. Saijo
  • Anticancer Res.
  • 1988
1 Excerpt

Bidcntate hydroxycarboxylic acid platinuni(II) complexes with antitumor activity

  • K Sato.
  • Nijhoff Publishing,
  • 1988

Similar Papers

Loading similar papers…