Phase I metabolism of the highly potent synthetic cannabinoid MDMB-CHMICA and detection in human urine samples.

@article{Franz2017PhaseIM,
  title={Phase I metabolism of the highly potent synthetic cannabinoid MDMB-CHMICA and detection in human urine samples.},
  author={Florian Franz and Verena Angerer and Bjoern Moosmann and Volker Auw{\"a}rter},
  journal={Drug testing and analysis},
  year={2017},
  volume={9 5},
  pages={744-753}
}
Among the recently emerged synthetic cannabinoids, MDMB-CHMICA (methyl N-{[1-(cyclohexylmethyl)-1H-indol-3-yl]carbonyl}-3-methylvalinate) shows an extraordinarily high prevalence in intoxication cases, necessitating analytical methods capable of detecting drug uptake. In this study, the in vivo phase I metabolism of MDMB-CHMICA was investigated using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and liquid chromatography-electrospray ionization-quadrupole… CONTINUE READING
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