Phase I drug combination trial design: walking the tightrope.

  title={Phase I drug combination trial design: walking the tightrope.},
  author={Paul Hamberg and Jaap Verweij},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={27 27},
Drug combination strategies are used in the palliative and curative settings for patients with cancer. Before a specific drug is incorporated into such a combination treatment strategy, it has to be explored using the clinical drug development route. The first critical step is the design of a combination phase I trial. As for all phase I trials, the design of a phase I drug combination trial is of utmost importance because it will dictate the course of the trial and, by its nature, it already… CONTINUE READING