Phase I dose escalation of single-agent vinblastine in dogs.

  title={Phase I dose escalation of single-agent vinblastine in dogs.},
  author={Dennis B. Bailey and Kenneth M. Rassnick and O. A. Kristal and John D Chretin and Cheryl E. Balkman},
  journal={Journal of veterinary internal medicine},
  volume={22 6},
BACKGROUND Vinblastine (VBL) is commonly used in dogs at a dosage of 2.0 mg/m2. The minimal toxicity observed at this dosage indicates that higher dosages might be well tolerated. HYPOTHESIS The maximum tolerated dosage (MTD) for a single VBL treatment is higher than the previously published dosage of 2.0 mg/m2. ANIMALS Twenty-three dogs with lymphoma or cutaneous mast cell tumors. METHODS Dogs received 1 single-agent VBL treatment IV. The starting dosage was 3.0 mg/m2, and dosages were… CONTINUE READING

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