Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease

  title={Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease},
  author={Zhijian Yang and You-rong Zhang and Bo Chen and Shu-lan Zhang and En-Zhi Jia and Liansheng Wang and Tie-bing Zhu and Chun-jian Li and Hui Wang and Jun Huang and Ke-jiang Cao and Wen-zhu Ma and Bin Wu and Li-Sheng Wang and Chu-Tse Wu},
  journal={Molecular Biology Reports},
Objective Therapeutic angiogenesis is a new strategy for treatment of vascular insufficiency. Hepatocyte growth factor (HGF)-induced angiogenesis has been applied to induce the neovascularization of ischemic adult tissues in preclinical studies. This report summarizes a phase I clinical trial on the safety of adenovirus-mediated human HGF (Ad-HGF) gene transfer to treat clinically significant coronary artery disease. Methods The 18 patients with severe and diffused triple vessel disease… 

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Overall, the present in vivo experiments demonstrated that intramyocardial injection of human HGF plasmid DNA in ischemic cardiomyopathy resulted in a significant improvement in cardiac function through an increase in blood flow and decrease in fibrosis, suggesting potential utility to treat patients with isChemic heart disease using HGF gene transfer.

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