Phase I clinical trial of safety of L-serine for ALS patients

  title={Phase I clinical trial of safety of L-serine for ALS patients},
  author={Todd D. Levine and Robert G. Miller and Walter G Bradley and D. Moore and David S. Saperstein and Lynne E Flynn and Jonathan S. Katz and Dallas A. Forshew and James S Metcalf and Sandra Anne Banack and Paul Alan Cox},
  journal={Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration},
  pages={107 - 111}
Abstract We performed a randomized, double-blind phase I clinical trial for six months on the effects of oral L-serine in patients with ALS. The protocol called for enrollment of patients with a diagnosis of probable or definite ALS, age 18–85 years, disease duration of less than three years and forced vital capacity (FVC) ≥ 60%. Patients were randomly assigned to four different oral twice-daily dose regimens (0.5, 2.5, 7.5, or 15 g/dose). Blood, urine and CSF samples, ALS Functional Rating… 
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Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of l-Serine
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Mechanisms of l-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L
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l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
ABSTRACT Background Multisite pain, including low-back and knee pain, is a major health issue that greatly decreases quality of life. Objectives This study analyzed the effects of l-serine, which
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l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND
It is demonstrated that chronic dietary exposure to BMAA causes ALS/MND-type pathological changes in the vervet and coadministration of l-serine reduces the amount of reactive gliosis and the number of protein inclusions in motor neurons.


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The ALSFRSr predicts survival time in an ALS clinic population
In an ALS clinic population, the total Amyotrophic Lateral Sclerosis Functional Rating Scale–revised score at baseline is a strong predictor of death or tracheostomy independently of forced vital capacity and after adjustment for age at baseline, sex, and symptom duration.
Detection of BMAA in the human central nervous system
Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis
  • F. Baumann, R. Henderson, P. Mccombe
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2010
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Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
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Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease
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Methods that may be used to assess exposure to cyanobacteria, and hence potentially to BMAA, are described, namely an epidemiologic questionnaire and direct and indirect methods for estimating the cyanobacterial load in ecosystems.
Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
It is found that while chronic exposure to the environmental toxin BMAA can trigger neurodegeneration in vulnerable individuals, increasing the amount of l-serine in the diet can reduce the risk.
Cerebral uptake and protein incorporation of cyanobacterial toxin &bgr;-N-methylamino-L-alanine
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