Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis

Abstract

A phase I study of intrathecal (IT) gemcitabine was performed to define a safe dose and characterize the toxicity profile and CSF pharmacokinetics of gemcitabine and its major metabolite 2′,2′-difluoro-deoxyuridine (dFdU) in patients 3 years of age and older with neoplastic meningitis. Gemcitabine was administered via Ommaya reservoir or lumbar puncture at… (More)
DOI: 10.1007/s00280-007-0601-x

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