Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study.

@article{Kisseberth2008PhaseIC,
  title={Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study.},
  author={William C. Kisseberth and David M. Vail and Jill E Yaissle and K. Ann Jeglum and C. Guillermo Couto and Heather L Ward and C. K. Raghul Khanna and Joyce E. Obradovich},
  journal={Journal of veterinary internal medicine},
  year={2008},
  volume={22 1},
  pages={
          83-8
        }
}
BACKGROUND The dosage of carboplatin in cats has been reported anecdotally and experimentally in non-tumor-bearing cats, but the dosage for carboplatin treatment in tumor-bearing cats has yet to be defined in a prospective clinical trial. PURPOSE To determine the maximally tolerated dose (MTD) and dose-limiting toxicosis (DLT) of carboplatin in tumor-bearing cats. CATS: Fifty-nine cats with measurable solid tumors. METHODS The starting dose of carboplatin was 160 mg/m(2) of body surface… CONTINUE READING
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