Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours

Abstract

Background:This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD) and pharmacokinetics of two dosing schedules of oral topotecan in combination with pazopanib in patients with advanced solid tumours.Methods:Stage I of this study was to determine whether there was an impact of pazopanib on topotecan exposure. In stage II, the MTD… (More)
DOI: 10.1038/bjc.2015.257

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@inproceedings{Kerklaan2015PhaseIA, title={Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours}, author={Bojana Milojkovic Kerklaan and Martijn P. J. Lolkema and Lot A. Devriese and Emile Eugene Voest and A Nol-Boekel and Marja W J Mergui-Roelvink and Marlies H. G. Langenberg and Kristine Mykulowycz and J Stoebenau and Spencer Lane and Philippe Legenne and Paul Stephen Wissel and D. Alastair Smith and Bruce J. Giantonio and Jan H M Schellens and Petronella Els O Witteveen}, booktitle={British Journal of Cancer}, year={2015} }