Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone.

@article{Petty2009PhaseIA,
  title={Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone.},
  author={W Jeffrey Petty and Antonius A. Miller and Thomas P McCoy and Patricia E. Gallagher and E. Ann Tallant and Frank M. Torti},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 23},
  pages={7398-404}
}
PURPOSE Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide hormone of the renin-angiotensin system with antiproliferative and antiangiogenic properties. The primary objective of this study was to establish the recommended phase II dose of Ang-(1-7) for treating patients with advanced cancer. Secondary objectives were to assess toxicities, pharmacokinetics, clinical activity, and plasma biomarkers. EXPERIMENTAL DESIGN Patients with advanced solid tumors refractory to standard therapy were… CONTINUE READING

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