Phase I and pharmacokinetic evaluations of UFT plus oral leucovorin.

@article{Pazdur1997PhaseIA,
  title={Phase I and pharmacokinetic evaluations of UFT plus oral leucovorin.},
  author={Richard Pazdur},
  journal={Oncology},
  year={1997},
  volume={11 9 Suppl 10},
  pages={35-9}
}
The phase I development program of tegafur and uracil (UFT) in the United States has included evaluation of the drug as a single agent and subsequent studies of its biochemical modulation by oral leucovorin. Phase I trials of single-agent UFT examined both a 5-day schedule repeated every 21 days and a 28-day schedule repeated every 35 days. In all of the trials the total dose was divided by three and administered three times daily at 8-hour intervals. Like intravenous schedules of fluorouracil… CONTINUE READING
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Phase II pharmacology study of UFT (BMS-200604) and leucovorin in refractory colorectal cancer patients

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  • Proc Am Soc Clin Oncol 16:270,
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6 Excerpts

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6 Excerpts

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3 Excerpts

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2 Excerpts

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2 Excerpts

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1 Excerpt

The Advanced Colorectal Cancer Meta - analysis Project : Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer . Evidence in terms of response rate

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