Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds.

@article{Pang2016PhaseIM,
  title={Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds.},
  author={Yi Yun Pang and Yee Min Tan and Eric Chun Yong Chan and Han Kiat Ho},
  journal={Chemical research in toxicology},
  year={2016},
  volume={29 7},
  pages={1118-31}
}
Diclofenac and lumiracoxib are two highly analogous 2-phenylaminophenylacetic acid anti-inflammatory drugs exhibiting occasional dose-limiting hepatotoxicities. Prior data indicate that bioactivation and reactive metabolite formation play roles in the observed toxicity, but the exact chemical influence of the substituents remains elusive. In order to elucidate the role of chemical influence on metabolism related toxicity, metabolic stability and electrophilic reactivity were investigated for a… CONTINUE READING