Phase I-II trial of concurrent capecitabine and oxaliplatin with preoperative intensity-modulated radiotherapy in patients with locally advanced rectal cancer.

@article{Aristu2008PhaseIT,
  title={Phase I-II trial of concurrent capecitabine and oxaliplatin with preoperative intensity-modulated radiotherapy in patients with locally advanced rectal cancer.},
  author={Jos{\'e} Javier Aristu and Leire Arbea and Javier Saiz Rodr{\'i}guez and Jos{\'e} Lu{\'i}s Hern{\'a}ndez-Lizo{\'a}in and Jes{\'u}s Javier Sola and Marta Nieto Moreno and Juan Diego Azcona and Juan Antonio D{\'i}az-Gonz{\'a}lez and Jes{\'u}s Miguel Garc{\'i}a-Foncillas and Rafael Mart{\'i}nez-Monge},
  journal={International journal of radiation oncology, biology, physics},
  year={2008},
  volume={71 3},
  pages={748-55}
}
PURPOSE To identify the maximal tolerated dose level of preoperative intensity-modulated radiotherapy combined with capecitabine and oxaliplatin and to evaluate the efficacy. PATIENTS AND METHODS Patients with rectal T3-T4 and/or N0-N+ rectal cancer received capecitabine 825 mg/m(2) twice daily Monday through Friday and oxaliplatin 60 mg/m(2) intravenously on Days 1, 8, and 15, concurrently with intensity-modulated radiotherapy. The radiation dose was increased in 5.0-Gy steps in cohorts of 3… CONTINUE READING
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