Phase I-II trial of concomitant pre-operative hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers.

3678 Background: To determine the maximum tolerated dose (MTD) of gemcitabine when administered concomitantly with hyperfractionated radiotherapy (RT) preoperatively in patients with locally advanced rectal cancers and to investigate the mid-term efficacy of such a regimen. METHODS 37 patients with stages II-III tumors were enrolled. RT consisted in 50 Gy… (More)