Phase I-II study of irinotecan combined with mitomycin-C in patients with advanced gastric cancer.

@article{Yamao2001PhaseIS,
  title={Phase I-II study of irinotecan combined with mitomycin-C in patients with advanced gastric cancer.},
  author={Takekazu Yamao and Kuniaki Shirao and Yasuhiro Matsumura and Kei Muro and Yasuhide Yamada and Masahiro Goto and Keisho Ch{\`i}n and Yasuhiro Shimada},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2001},
  volume={12 12},
  pages={1729-35}
}
BACKGROUND Irinotecan (CPT-11) shows synergism with mitomycin-C (MMC) in a preclinical setting. The goals of this study were to determine the maximum tolerated dose (MTD), the dose limiting toxicity, the recommended dose (RD), and preliminary anti-tumor activity in a combined CPT-11 and MMC treatment of advanced gastric cancer. PATIENTS AND METHODS The study was designed to evaluate escalated doses of CPT-11 and MMC administered every two weeks. Five escalating dose levels were studied (CPT… CONTINUE READING
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