Phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate in dogs with naturally occurring malignant tumors.

@article{Cai2016PhaseIC,
  title={Phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate in dogs with naturally occurring malignant tumors.},
  author={Shuang Cai and Ti Zhang and Wai Chee Forrest and Qiuhong Yang and Chad E. Groer and Eva Mohr and Daniel J. Aires and Sandra M. Axiak-Bechtel and Brian K Flesner and C J Henry and Kimberly A Selting and Deborah Tate and Jeffrey Swarz and Jeffrey N Bryan and M Laird Forrest},
  journal={American journal of veterinary research},
  year={2016},
  volume={77 9},
  pages={1005-16}
}
OBJECTIVE To conduct a phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate (HA-Pt) in dogs with naturally occurring malignant tumors. ANIMALS 18 healthy rats, 9 healthy mice, and 16 dogs with cancer. PROCEDURES HA-Pt was prepared and tested by inductively coupled plasma mass spectrometry; DNA-platinum adduct formation and antiproliferation… CONTINUE READING