Phase I Clinical and Pharmacological Studies of Benzylacyclouridine, a Uridine Phosphorylase Inhibitor1

  • Giuseppe Pizzonno, Lonnin Yee, +8 authors Paul Calabresi
  • Published 2005

Abstract

Benzylacyclouridine (BAU, IND 039655) is a potent and specific inhibitor of uridine phosphorylase (UrdPase; EC 2.4.2.3). This enzyme plays a major role in regulating undine horneostasis and also catalyzes the conversion of fluoropynimidine nucleosides to their respective bases. Inhibition of UrdPase enzyme activity i8-24 h after 5-fluorouracil (5-FU… (More)

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Cite this paper

@inproceedings{Pizzonno2005PhaseIC, title={Phase I Clinical and Pharmacological Studies of Benzylacyclouridine, a Uridine Phosphorylase Inhibitor1}, author={Giuseppe Pizzonno and Lonnin Yee and Barbara A. Buntness and John Marsh and James W. Dannowski and Ming Yu W. Chu and Shih Hsi Chu and Edward Chu and Janine J. Leffent and Robert E. Handschumacher and Paul Calabresi}, year={2005} }