Phase I/Pilot Study of SU5416 (Semaxinib) in Combination With Irinotecan/Bolus 5-FU/LV (IFL) in Patients With Metastatic Colorectal Cancer

@article{Lockhart2006PhaseIS,
  title={Phase I/Pilot Study of SU5416 (Semaxinib) in Combination With Irinotecan/Bolus 5-FU/LV (IFL) in Patients With Metastatic Colorectal Cancer},
  author={A Craig Lockhart and Gillian F. Cropp and Jordan D. Berlin and Edwin F. Donnelly and Robert D Schumaker and Larry J. Schaaf and Kenneth R. Hande and Arthur C. Fleischer and Alison L. Hannah and Mace L. Rothenberg},
  journal={American Journal of Clinical Oncology},
  year={2006},
  volume={29},
  pages={109-115}
}
Objectives:Determine the toxicity, tolerability, and pharmacokinetics of SU5416, a vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, coadministered with bolus 5-fluorouracil (5-FU), leucovorin, and irinotecan (IFL) in untreated patients with metastatic colorectal cancer. Methods:SU5416 (85 or 145 mg/m2) was administered twice weekly throughout a 6-week period along with standard IFL (4 weeks on/2 weeks off). Plasma samples were assayed for SU5416, irinotecan… 
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