Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.

@article{Mizumoto2010PhaseIT,
  title={Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.},
  author={Masashi Mizumoto and Koji Tsuboi and Hiroshi Igaki and Tetsuya Yamamoto and Shingo Takano and Yoshiko Oshiro and Yasutaka Hayashi and Haruko Hashii and Ayae Kanemoto and Hidetsugu Nakayama and Shinji Sugahara and Hideyuki Sakurai and Akira Matsumura and Koichi Tokuuye},
  journal={International journal of radiation oncology, biology, physics},
  year={2010},
  volume={77 1},
  pages={
          98-105
        }
}
PURPOSE To evaluate the safety and efficacy of postoperative hyperfractionated concomitant boost proton radiotherapy with nimustine hydrochloride for supratentorial glioblastoma multiforme (GBM). METHODS AND MATERIALS Twenty patients with histologically confirmed supratentorial GBM met the following criteria: (1) a Karnofsky performance status of >or=60; (2) the diameter of the enhanced area before radiotherapy was <or=40 cm; and (3) the enhanced area did not extend to the brain stem… CONTINUE READING
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