Phase I/II trial of HIV-1 hyperimmune globulin for the prevention of HIV-1 vertical transmission in Uganda.


OBJECTIVES To assess the safety, tolerance, pharmacokinetics, and virologic and immunologic changes associated with the use of Ugandan HIV hyperimmune globulin (HIVIGLOB) in HIV infected pregnant Ugandan women and their infants. DESIGN A prospective, phase I/II, three-arm dose escalation trial of HIVIGLOB. METHODS HIVIGLOB was prepared from discarded… (More)