Phase I/II study of paclitaxel and vinorelbine in metastatic breast cancer

@article{Tortoriello1998PhaseIS,
  title={Phase I/II study of paclitaxel and vinorelbine in metastatic breast cancer},
  author={Anna Tortoriello and Gaetano Facchini and Francesco Caponigro and M. Soledad P{\'e}rez Santangelo and Giacomo Benassai and Giovanni Persico and Antonio Citarella and Maria Carola and Nicola Marzano and Rosario Vincenzo Iaffaioli},
  journal={Breast Cancer Research and Treatment},
  year={1998},
  volume={47},
  pages={91-97}
}
Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer. Both in vitro and in vivo studies have shown that the combined administration of these two microtubule-targeting agents is feasible and worthwhile. Based on the promising preclinical data, patients with metastatic breast cancer no longer amenable to conventional treatment were entered into a phase I/II study in which the vinorelbine dose was fixed at 30 mg/sqm and paclitaxel was started at 90 mg/sqm and… CONTINUE READING

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