Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis

@inproceedings{Fushida2013PhaseIS,
  title={Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis},
  author={Sachio Fushida and Jun Kinoshita and M Mohammadi Kaji and Yosuke Hirono and Fuminori Goda and Yasumichi Yagi and Katsunobu Oyama and Yoshio Sudo and Yoshito Watanabe and Takashi Fujimura},
  booktitle={Cancer Chemotherapy and Pharmacology},
  year={2013}
}
PurposeWe designed a phase I/II trial of intraperitoneal (IP) docetaxel plus S-1 to determine the maximum tolerated dose (MTD) and recommended dose (RD) and to evaluate its efficacy and safety in gastric cancer patients with peritoneal carcinomatosis (PC).MethodsPatients with PC confirmed by laparoscopy or laparotomy received IP docetaxel on days 1 and 15 and S-1 (80 mg/m2) on days 1–14 every 4 weeks.ResultsIn the phase I part (n = 12), each cohort received escalating doses of docetaxel (35–50… CONTINUE READING
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