Phase I/II study of docetaxel and S-1 in patients with advanced gastric cancer

@article{Yamaguchi2006PhaseIS,
  title={Phase I/II study of docetaxel and S-1 in patients with advanced gastric cancer},
  author={Kensei Yamaguchi and Tomotaka Shimamura and Ichinosuke Hyodo and Wasaburo Koizumi and Toshihiko Doi and Hiroyuki Narahara and Yoshito Komatsu and Takashi Kato and Soh Saitoh and Toshikazu Akiya and Masaki Munakata and Yoshinori Miyata and Yoshifumi Maeda and Hiroya Takiuchi and Shyuji Nakano and Taito Esaki and Fukunori Kinjo and Yuh Sakata},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={1803 - 1808}
}
The aims of this phase I/II study of docetaxel and S-1 were to determine the dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), and recommended dose (RD) in the phase I part and to explore the tumour response, survival and safety in the phase II part. Patients with histologically- or cytologically confirmed unresectable or recurrent gastric cancer were eligible. Treatment consisted of intravenous docetaxel on day 1 (starting dose 50 mg m−2) and oral S-1 at a fixed dose of 40 mg m−2… CONTINUE READING

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