Phase I/II study of a fine-powder formulation of cisplatin for transcatheter arterial chemoembolization in hepatocellular carcinoma.

@article{Moriguchi2010PhaseIS,
  title={Phase I/II study of a fine-powder formulation of cisplatin for transcatheter arterial chemoembolization in hepatocellular carcinoma.},
  author={Masamichi Moriguchi and Tadatoshi Takayama and Masahiko Nakamura and Osamu Aramaki and Tokio Higaki and Hisashi Nakayama and Takao Ohkubo and Masashi Fujii},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2010},
  volume={40 4},
  pages={369-75}
}
AIM The clinical feasibility of transcatheter arterial chemoembolization (TACE) with fine-powder cisplatin (CDDP) in patients with hepatocellular carcinoma (HCC) has not been investigated. A phase I/II study was conducted to investigate the safety and tolerability of fine-powder CDDP when it was used with lipiodol and gelatin sponge particles for TACE. METHODS Fine-powder CDDP emulsified in lipiodol was injected into tumor arteries. Embolization was subsequently performed with gelatin sponge… CONTINUE READING

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