Phase I/II evaluation of Pentostatin (2′-deoxycoformycin) in a five day schedule for the treatment of relapsed/refractory B-cell chronic lymphocytic leukaemia

@article{Johnson1998PhaseIE,
  title={Phase I/II evaluation of Pentostatin (2′-deoxycoformycin) in a five day schedule for the treatment of relapsed/refractory B-cell chronic lymphocytic leukaemia},
  author={Stephen A N Johnson and Daniel Catovsky and J. Anthony Child and Adrian C. Newland and Donald W. Milligan and Riaz Janmohamed},
  journal={Investigational New Drugs},
  year={1998},
  volume={16},
  pages={155-160}
}
The purpose of this study was to determine the efficacy and toxicity of pentostatin (2′-deoxycoformycin) administered in a five day schedule every 28 days to patients with B-cell chronic lymphocytic leukaemia (B-CLL) relapsed from or refractory to at least one line of prior chemotherapy. The initial dose level of 2 mg/m2/day was adjusted up or down by 0.5 mg/m2 in subsequent cycles on the basis of haematological and non-haematological toxicities. The five day schedule was selected because… CONTINUE READING
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