Phase I/IB study of immunization with autologous tumor cells transfected with the GM-CSF gene by particle-mediated transfer in patients with melanoma or sarcoma.

@article{Mahvi1997PhaseIS,
  title={Phase I/IB study of immunization with autologous tumor cells transfected with the GM-CSF gene by particle-mediated transfer in patients with melanoma or sarcoma.},
  author={David M. Mahvi and Paul M. Sondel and N S Yang and Mark R Albertini and Joan Hoff Schiller and Jacquelyn A. Hank and John Heiner and J. -L. Gan and William Swain and Roberto Logro{\~n}o},
  journal={Human gene therapy},
  year={1997},
  volume={8 7},
  pages={875-91}
}
The objective of this Phase I study is to assess the acute and long-term toxicities of intradermal vaccination of cancer patients with lethally-irradiated tumor cells that have been transfected by particle-mediated gene transfer (PMGT) with gold particles coated with human granulocyte-macrophage colony stimulating factor (GM-CSF) DNA in a plasmid expression vector. The GM-CSF DNA-coated gold particles are delivered to tumor cells using helium pressure with a hand held gene delivery device… CONTINUE READING