Phase Diagrams and Ordering in Charged Membranes: Binary Mixtures of Charged and Neutral Lipids.

  title={Phase Diagrams and Ordering in Charged Membranes: Binary Mixtures of Charged and Neutral Lipids.},
  author={Naofumi Shimokawa and Hiroki Himeno and Tsutomu Hamada and Masahiro Takagi and Shigeyuki Komura and David Andelman},
  journal={The journal of physical chemistry. B},
  volume={120 26},
We propose a model describing the phase behavior of two-component membranes consisting of binary mixtures of electrically charged and neutral lipids. We take into account the structural phase transition (main-transition) of the hydrocarbon chains, and investigate the interplay between this phase transition and the lateral phase separation. The presence of charged lipids significantly affects the phase behavior of the multicomponent membrane. Due to the conservation of lipid molecular volume… 
8 Citations

Figures and Tables from this paper

Three-Phase Coexistence in Binary Charged Lipid Membranes in a Hypotonic Solution.
Attraction mediated by hydrogen bonding between protonated DOPS molecules and reduction of the electrostatic interactions at the domain boundaries stabilized the three-phase coexistence.
Coarse-grained molecular dynamics simulation for uptake of nanoparticles into a charged lipid vesicle dominated by electrostatic interactions.
A coarse-grained molecular dynamics simulation is used to investigate the interaction between neutral or charged nanoparticles (NPs) and a vesicle consisting of neutral and negatively charged lipids and reveals how the NP's behavior depends on the NP valence, size, and the nonelectrostatic interaction parameters.
Formation of modulated phases and domain rigidification in fatty acid-containing lipid membranes.
The result showed that oleic acid and phytanic acid- containing vesicles as well as palmitic acid-containing vesicle are not spherical, and this domain-induced deformation is explained theoretically.
2D lattice model of a lipid bilayer: Microscopic derivation and thermodynamic exploration.
From the properties of the 2D lattice model one can directly read off the enthalpy and entropy change of the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine gel-to-liquid transition in excellent agreement with experimental and MD results.
Influence of Charge Lipid Head Group Structures on Electric Double Layer Properties.
A model for a multicomponent lipid monolayer in contact with an aqueous solution by means of a generalized classical density functional theory and Monte Carlo simulations suggests that the dominant effect on the lipid head group conformation is from the charge density of the interface and the structured lipid mole fraction in the monolayers.
Structure of Lung-Mimetic Multilamellar Bodies with Lipid Compositions Relevant in Pneumonia.
This work conjecture that CL overexpressed in the hypophase of alveoli strongly affects the structure of lung-lipid bilayers and their stacking in the MLBs, and proposes how alteration of the physiochemical properties of MLBs can critically impact the breathing cycle.
Long-lived ionic nano-domains can modulate the stiffness of soft interfaces.
This work identifies two distinct ionic states: the well-known direct electrostatic interaction with lipid headgroups and a water-mediated interaction that can drive the formation of remarkably long-lived ionic networks which evolve over many seconds.


Charge-induced phase separation in lipid membranes.
The addition of DPPG((-)) to a binary mixture of DPPC/cholesterol induces phase separation between DPPG-rich and cholesterol-rich phases, which indicates that cholesterol localization depends strongly on the electric charge on the hydrophilic head group rather than on the ordering of the hydrocarbon tails.
Phenomenological model and phase behavior of saturated and unsaturated lipids and cholesterol.
The theory addresses the means by which cholesterol-mediated ordering of membrane lipids leads to liquid-liquid immiscibility, and produces phase diagrams in which there can be liquid- liquid phase separation in the ternary system but not in any of the binary ones.
Lateral phase separation in mixtures of lipids and cholesterol
In an effort to understand "rafts" in biological membranes, phenomenological models for saturated and unsaturated lipid mixtures, and lipid-cholesterol mixtures are proposed and regions in the ternary phase diagram of lipid/lipid/cholesterol systems are applied.
Charged bilayer membranes in asymmetric ionic solutions: phase diagrams and critical behavior.
We consider the phase separation in an asymmetrically charged lipid bilayer membrane consisting of neutral and negatively charged lipids that are in contact with in and out ionic solutions having
Phase Separations in Phospholipid Membranes
Phase diagrams representing lateral phase separations in the plane of lipid bilayer membranes have been determined for binary mixtures containing dielaidoylphosphatidylcholine together with
Vesicles with charged domains.
Phase behaviour of three-component lipid mixtures
To describe the lateral phase separation in biological membranes, we propose phenomenological models for binary and ternary lipid mixtures. We consider a coupling between the local lipid composition