Phase Composition Control in Microsphere-Supported Biomembrane Systems.

  title={Phase Composition Control in Microsphere-Supported Biomembrane Systems.},
  author={E. Schuyler Fried and Yue-Ming Li and M Lane Gilchrist},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  volume={33 12},
The popularization of studies in membrane protein lipid phase coexistence has prompted the development of new techniques to construct and study biomimetic systems with cholesterol-rich lipid microdomains. Here, microsphere-supported biomembranes with integrated α-helical peptides, referred to as proteolipobeads (PLBs), were used to model peptide/protein partitioning within DOPC/DPPC/cholesterol phase-separated membranes. Due to the appearance of compositional heterogeneity and impurities in the… CONTINUE READING
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